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- macOS Sierra 10.12: Support begins with R2016b
- Ubuntu 16.04 LTS: Support begins with R2016b
- Windows Server 2008 Service Pack 2: Support was dropped as of R2016b.
- SUSE Linux Enterprise Desktop 11: Support was dropped as of R2016b.
- To address the ever growing needs of data management in the lab, a Columbia University post-doc created Stirplate.io, a free platform for scientists to store, share and analyze data in the cloud.